2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132171
    DSM705
    		Inhibitor
    DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound.
    DSM705
  • HY-12054A
    Hesperadin hydrochloride
    		Inhibitor
    Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM.
    Hesperadin hydrochloride
  • HY-N1584B
    Halofuginone hydrochloride
    		Inhibitor
    Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
    Halofuginone hydrochloride
  • HY-B0497A
    Niclosamide sodium
    		Inhibitor
    Niclosamide (BAY2353) sodium is an orally active antihelminthic agent used in parasitic infection research. Niclosamide sodium is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide sodium has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.
    Niclosamide sodium
  • HY-B0433B
    Quinine hemisulfate
    		Inhibitor
    Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
    Quinine hemisulfate
  • HY-B1198S
    Piperonyl butoxide-d9
    		Inhibitor
    Piperonyl butoxide-d9 is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice.
    Piperonyl butoxide-d<sub>9</sub>
  • HY-B1118S
    Secnidazole-d6
    		Inhibitor
    Secnidazole-d6 is the deuterium labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research[1].
    Secnidazole-d<sub>6</sub>
  • HY-107483S
    Cambendazole-d7
    Cambendazole-d7 is the deuterium labeled Cambendazole[1].
    Cambendazole-d<sub>7</sub>
  • HY-136440S
    Hydroxymetronidazole-d4
    		Inhibitor
    Hydroxymetronidazole-d4 is the deuterium labeled Hydroxymetronidazole. Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle[1].
    Hydroxymetronidazole-d<sub>4</sub>
  • HY-135811S
    Desethyl chloroquine-d4
    		Inhibitor
    Desethyl chloroquine-d4 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].
    Desethyl chloroquine-d<sub>4</sub>
  • HY-N0176S
    Dihydroartemisinin-d3
    		Inhibitor
    Dihydroartemisinin-d3 is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.
    Dihydroartemisinin-d<sub>3</sub>
  • HY-18719ES
    Endoxifen-d5
    		Inhibitor
    Endoxifen-d5 is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].
    Endoxifen-d<sub>5</sub>
  • HY-B0806AS
    Proguanil-d4 hydrochloride
    		Inhibitor
    Proguanil-d4 (hydrochloride) is the deuterium labeled Proguanil hydrochloride. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].
    Proguanil-d<sub>4</sub> hydrochloride
  • HY-B0223S2
    Albendazole-d7
    		Inhibitor
    Albendazole-d7 is the deuterium labeled Albendazole. Albendazole is a broad-spectrum parasiticide with high effectiveness and low host toxicity. Albendazole is used for the research gastrointestinal parasites in humans and animals[1][2].
    Albendazole-d<sub>7</sub>
  • HY-13832S2
    Atovaquone-d5
    		Inhibitor
    Atovaquone-d5 is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
    Atovaquone-d<sub>5</sub>
  • HY-B0094S
    Artemisinin-d3
    		Activator
    Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
    Artemisinin-d<sub>3</sub>
  • HY-147002
    7-O-Methyl Ivermectin B1a
    		Inhibitor
    7-O-Methyl Ivermectin B1a is an analogue of Ivermectin B1a (HY-126937).
    7-O-Methyl Ivermectin B1a
  • HY-155087
    Anticancer agent 140
    		Inhibitor
    Anticancer agent 140 (Compd 3) is a compound with potential anticancer and antiparasitic activities.
    Anticancer agent 140
  • HY-107771R
    Fluensulfone (Standard)
    		Inhibitor
    Propane sultone (Standard) is the analytical standard of Propane sultone. This product is intended for research and analytical applications. Propane sultone is a versatile intermediate. Propane sultone is utilized as an additive in the electrolyte in lithium battery. Propane sultone combines with cellulose and carbohydrate, that can be used in sizing, printing and textile. Propane sultone is utilized in dye manufacture.
    Fluensulfone (Standard)
  • HY-N2381R
    Menthone (Standard)
    		Inhibitor
    Menthone (Standard) is the analytical standard of Menthone. This product is intended for research and analytical applications. Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.
    Menthone (Standard)
Parasite Isoform Comparison

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